Target name

Q9H3N8: Histamine H4 receptor


  Protein function

The H4 subclass of histamine receptors could mediate the histamine signals in peripheral tissues. Displays a significant level of constitutive activity (spontaneous activity in the absence of agonist).

  Database links

Uniprot primary ID Q9H3N8
PDB ID
DrugBank ID DB06148 DB01142 DB00667 DB00477 DB00334 DB00321 DB00408
BioGrid ID
GuidetoPHARMACOLOGY ID 265
PharmGKB ID PA134982275
KEGG ID hsa:59340
DIP ID
STRING ID 9606.ENSP00000256906
IntAct ID
DMDM 14194819
BRENDA
Reactome R-HSA-418594 R-HSA-390650
SignaLink
BioCyc
Entrez Gene (Gene ID) 59340
BindingDB Q9H3N8

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.910 0.000 0.950 0.003 0.930 0.000 0.930 0.000 0.970 0.000 0.858 0.004 Download
Estate fingerprints 0.915 0.005 0.883 0.005 0.899 0.003 0.900 0.000 0.950 0.000 0.794 0.005 Download
MACCS fingerprints 0.919 0.003 0.879 0.004 0.899 0.003 0.900 0.000 0.960 0.000 0.792 0.004 Download
Daylight fingerprints 0.855 0.005 0.837 0.000 0.846 0.005 0.849 0.003 0.890 0.000 0.690 0.000 Download
ECFP2 fingerprints 0.958 0.004 0.942 0.005 0.950 0.000 0.952 0.004 0.990 0.000 0.904 0.005 Download
ECFP4 fingerprints 0.958 0.004 0.982 0.005 0.970 0.000 0.970 0.000 0.990 0.000 0.931 0.003 Download
ECFP6 fingerprints 0.950 0.000 0.990 0.005 0.970 0.000 0.968 0.004 0.990 0.000 0.936 0.005 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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