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E-mail: biomed@csu.edu.cn
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Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). Probably represents the last step of maturation of gamma-secretase, facilitating endoproteolysis of presenilin and conferring gamma-secretase activity.
| Uniprot primary ID | Q9NZ42 |
| PDB ID | 5A63 |
| DrugBank ID | |
| BioGrid ID | 120953 |
| GuidetoPHARMACOLOGY ID | |
| PharmGKB ID | PA142671122 |
| KEGG ID | hsa:55851 |
| DIP ID | |
| STRING ID | 9606.ENSP00000222266 |
| IntAct ID | Q9NZ42 |
| DMDM | 37081820 |
| BRENDA | |
| Reactome | R-HSA-193692 R-HSA-1980150 R-HSA-1980148 R-HSA-2644606 R-HSA-3928665 R-HSA-205043 R-HSA-2122948 R-HSA-2894862 R-HSA-1251985 R-HSA-2979096 |
| SignaLink | Q9NZ42 |
| BioCyc | |
| Entrez Gene (Gene ID) | 55851 |
| BindingDB | Q9NZ42 |
| Fingerprint type | Sensitivity | SEN_std | Specificity | SPE_std | Accuracy | ACC_std | F1-score | F1-score_std | AUC | AUC_std | MCC | MCC_std | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.866 | 0.007 | 0.968 | 0.000 | 0.917 | 0.005 | 0.911 | 0.003 | 0.980 | 0.000 | 0.834 | 0.007 | Download |
| Estate fingerprints | 0.920 | 0.009 | 0.852 | 0.008 | 0.886 | 0.007 | 0.892 | 0.004 | 0.960 | 0.000 | 0.778 | 0.010 | Download |
| MACCS fingerprints | 0.790 | 0.000 | 0.870 | 0.000 | 0.830 | 0.000 | 0.820 | 0.000 | 0.930 | 0.000 | 0.650 | 0.000 | Download |
| Daylight fingerprints | 0.736 | 0.011 | 0.994 | 0.000 | 0.865 | 0.005 | 0.845 | 0.008 | 0.971 | 0.003 | 0.753 | 0.008 | Download |
| ECFP2 fingerprints | 0.981 | 0.006 | 0.973 | 0.003 | 0.977 | 0.005 | 0.977 | 0.005 | 1.000 | 0.000 | 0.952 | 0.006 | Download |
| ECFP4 fingerprints | 0.970 | 0.000 | 0.990 | 0.000 | 0.980 | 0.000 | 0.980 | 0.000 | 1.000 | 0.000 | 0.961 | 0.003 | Download |
| ECFP6 fingerprints | 0.962 | 0.008 | 0.992 | 0.005 | 0.977 | 0.005 | 0.977 | 0.005 | 0.999 | 0.003 | 0.953 | 0.007 | Download |
| Positive dataset | Negative dataset |
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E-mail: biomed@csu.edu.cn
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