Target name

Q9NZ42: Gamma-secretase subunit PEN-2


  Protein function

Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). Probably represents the last step of maturation of gamma-secretase, facilitating endoproteolysis of presenilin and conferring gamma-secretase activity.

  Database links

Uniprot primary ID Q9NZ42
PDB ID 5A63
DrugBank ID
BioGrid ID 120953
GuidetoPHARMACOLOGY ID
PharmGKB ID PA142671122
KEGG ID hsa:55851
DIP ID
STRING ID 9606.ENSP00000222266
IntAct ID Q9NZ42
DMDM 37081820
BRENDA
Reactome R-HSA-193692 R-HSA-1980150 R-HSA-1980148 R-HSA-2644606 R-HSA-3928665 R-HSA-205043 R-HSA-2122948 R-HSA-2894862 R-HSA-1251985 R-HSA-2979096
SignaLink Q9NZ42
BioCyc
Entrez Gene (Gene ID) 55851
BindingDB Q9NZ42

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.866 0.007 0.968 0.000 0.917 0.005 0.911 0.003 0.980 0.000 0.834 0.007 Download
Estate fingerprints 0.920 0.009 0.852 0.008 0.886 0.007 0.892 0.004 0.960 0.000 0.778 0.010 Download
MACCS fingerprints 0.790 0.000 0.870 0.000 0.830 0.000 0.820 0.000 0.930 0.000 0.650 0.000 Download
Daylight fingerprints 0.736 0.011 0.994 0.000 0.865 0.005 0.845 0.008 0.971 0.003 0.753 0.008 Download
ECFP2 fingerprints 0.981 0.006 0.973 0.003 0.977 0.005 0.977 0.005 1.000 0.000 0.952 0.006 Download
ECFP4 fingerprints 0.970 0.000 0.990 0.000 0.980 0.000 0.980 0.000 1.000 0.000 0.961 0.003 Download
ECFP6 fingerprints 0.962 0.008 0.992 0.005 0.977 0.005 0.977 0.005 0.999 0.003 0.953 0.007 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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