Target name

Q9P1W9: Serine/threonine-protein kinase pim-2


  Protein function

Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation. Exerts its oncogenic activity through: the regulation of MYC transcriptional activity, the regulation of cell cycle progression, the regulation of cap-dependent protein translation and through survival signaling by phosphorylation of a pro-apoptotic protein, BAD. Phosphorylation of MYC leads to an increase of MYC protein stability and thereby an increase transcriptional activity. The stabilization of MYC exerted by PIM2 might explain partly the strong synergism between these 2 oncogenes in tumorigenesis. Regulates cap-dependent protein translation in a mammalian target of rapamycin complex 1 (mTORC1)-independent manner and in parallel to the PI3K-Akt pathway. Mediates survival signaling through phosphorylation of BAD, which induces release of the anti-apoptotic protein Bcl-X(L)/BCL2L1. Promotes cell survival in response to a variety of proliferative signals via positive regulation of the I-kappa-B kinase/NF-kappa-B cascade; this process requires phosphorylation of MAP3K8/COT. Isoform 1 is less active in this respect. Promotes growth factor-independent proliferation by phosphorylation of cell cycle factors such as CDKN1A and CDKN1B. Involved in the positive regulation of chondrocyte survival and autophagy in the epiphyseal growth plate.

  Database links

Uniprot primary ID Q9P1W9
PDB ID 2IWI 4X7Q
DrugBank ID
BioGrid ID 116228
GuidetoPHARMACOLOGY ID 2159
PharmGKB ID PA33319
KEGG ID hsa:11040
DIP ID
STRING ID 9606.ENSP00000365692
IntAct ID Q9P1W9
DMDM 20139243
BRENDA
Reactome
SignaLink Q9P1W9
BioCyc
Entrez Gene (Gene ID) 11040
BindingDB Q9P1W9

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.910 0.000 0.950 0.005 0.930 0.000 0.930 0.000 0.973 0.005 0.864 0.005 Download
Estate fingerprints 0.734 0.005 0.742 0.005 0.738 0.004 0.738 0.004 0.840 0.000 0.473 0.005 Download
MACCS fingerprints 0.871 0.003 0.747 0.004 0.809 0.003 0.820 0.000 0.910 0.000 0.620 0.005 Download
Daylight fingerprints 0.779 0.003 0.921 0.000 0.850 0.000 0.839 0.003 0.910 0.000 0.707 0.005 Download
ECFP2 fingerprints 0.949 0.003 0.931 0.005 0.940 0.000 0.940 0.000 0.990 0.000 0.874 0.005 Download
ECFP4 fingerprints 0.940 0.000 0.980 0.000 0.960 0.000 0.960 0.000 0.990 0.000 0.923 0.005 Download
ECFP6 fingerprints 0.909 0.003 0.991 0.004 0.950 0.000 0.950 0.000 0.990 0.000 0.909 0.003 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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