Target name

Q9QYJ6: cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


  Protein function

Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. Can hydrolyze both cAMP and cGMP, but has higher affinity for cAMP and is more efficient with cAMP as substrate.

  Database links

Uniprot primary ID Q9QYJ6
PDB ID 3HR1 2OVV 2OVY 3QPP 3QPN 3QPO 3HQW 3LXG 3HQZ 3HQY 2O8H
DrugBank ID
BioGrid ID
GuidetoPHARMACOLOGY ID
PharmGKB ID
KEGG ID rno:63885
DIP ID
STRING ID 10116.ENSRNOP00000060834
IntAct ID
DMDM
BRENDA
Reactome R-RNO-418457 R-RNO-418555
SignaLink
BioCyc
Entrez Gene (Gene ID) 63885
BindingDB Q9QYJ6

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.980 0.000 0.974 0.005 0.977 0.005 0.977 0.005 0.990 0.000 0.952 0.004 Download
Estate fingerprints 0.926 0.005 0.906 0.000 0.916 0.005 0.920 0.000 0.965 0.005 0.834 0.005 Download
MACCS fingerprints 0.895 0.005 0.907 0.005 0.901 0.003 0.901 0.003 0.970 0.000 0.806 0.005 Download
Daylight fingerprints 0.858 0.011 0.990 0.004 0.924 0.007 0.921 0.009 0.990 0.000 0.858 0.011 Download
ECFP2 fingerprints 0.944 0.005 0.986 0.000 0.965 0.005 0.965 0.005 1.000 0.000 0.930 0.005 Download
ECFP4 fingerprints 0.979 0.003 1.000 0.000 0.990 0.000 0.990 0.000 1.000 0.000 0.979 0.003 Download
ECFP6 fingerprints 0.970 0.000 1.000 0.000 0.986 0.005 0.986 0.005 1.000 0.000 0.970 0.000 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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