Target name

Q9QYN8: Histamine H3 receptor


  Protein function

The H3 subclass of histamine receptors could mediate the histamine signals in CNS and peripheral nervous system. Signals through the inhibition of adenylate cyclase and displays high constitutive activity (spontaneous activity in the absence of agonist).

  Database links

Uniprot primary ID Q9QYN8
PDB ID
DrugBank ID
BioGrid ID
GuidetoPHARMACOLOGY ID 264
PharmGKB ID
KEGG ID rno:85268
DIP ID
STRING ID
IntAct ID
DMDM
BRENDA
Reactome R-RNO-418594 R-RNO-390650
SignaLink
BioCyc
Entrez Gene (Gene ID) 85268
BindingDB Q9QYN8

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.890 0.000 0.870 0.000 0.880 0.000 0.880 0.000 0.941 0.003 0.754 0.005 Download
Estate fingerprints 0.869 0.003 0.789 0.003 0.829 0.003 0.834 0.005 0.890 0.000 0.659 0.006 Download
MACCS fingerprints 0.912 0.004 0.808 0.000 0.860 0.000 0.862 0.004 0.930 0.000 0.719 0.003 Download
Daylight fingerprints 0.710 0.000 0.822 0.000 0.766 0.005 0.750 0.000 0.838 0.004 0.532 0.004 Download
ECFP2 fingerprints 0.970 0.000 0.950 0.000 0.960 0.000 0.960 0.000 0.990 0.000 0.922 0.004 Download
ECFP4 fingerprints 0.969 0.003 0.971 0.000 0.970 0.000 0.970 0.000 0.990 0.000 0.949 0.003 Download
ECFP6 fingerprints 0.953 0.005 0.987 0.000 0.970 0.000 0.970 0.000 0.990 0.000 0.945 0.005 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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