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E-mail: biomed@csu.edu.cn
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Receptor for cysteinyl leukotrienes mediating bronchoconstriction of individuals with and without asthma. Stimulation by LTD4 results in the contraction and proliferation of smooth muscle, edema, eosinophil migration and damage to the mucus layer in the lung. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. The rank order of affinities for the leukotrienes is LTD4 >> LTE4 = LTC4 >> LTB4.
| Uniprot primary ID | Q9Y271 |
| PDB ID | |
| DrugBank ID | DB01411 DB00471 DB00716 DB00549 DB00587 |
| BioGrid ID | 116014 |
| GuidetoPHARMACOLOGY ID | 269 |
| PharmGKB ID | PA38453 |
| KEGG ID | hsa:10800 |
| DIP ID | |
| STRING ID | 9606.ENSP00000362401 |
| IntAct ID | Q9Y271 |
| DMDM | 20138087 |
| BRENDA | |
| Reactome | R-HSA-391906 R-HSA-416476 |
| SignaLink | |
| BioCyc | |
| Entrez Gene (Gene ID) | 10800 |
| BindingDB | Q9Y271 |
| Fingerprint type | Sensitivity | SEN_std | Specificity | SPE_std | Accuracy | ACC_std | F1-score | F1-score_std | AUC | AUC_std | MCC | MCC_std | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.958 | 0.004 | 0.982 | 0.004 | 0.970 | 0.000 | 0.970 | 0.000 | 0.990 | 0.000 | 0.939 | 0.003 | Download |
| Estate fingerprints | 0.868 | 0.004 | 0.872 | 0.007 | 0.870 | 0.000 | 0.870 | 0.000 | 0.950 | 0.000 | 0.741 | 0.007 | Download |
| MACCS fingerprints | 0.887 | 0.007 | 0.907 | 0.005 | 0.897 | 0.007 | 0.897 | 0.007 | 0.970 | 0.000 | 0.797 | 0.007 | Download |
| Daylight fingerprints | 0.894 | 0.007 | 0.980 | 0.000 | 0.937 | 0.005 | 0.934 | 0.005 | 0.980 | 0.000 | 0.874 | 0.007 | Download |
| ECFP2 fingerprints | 0.952 | 0.004 | 0.976 | 0.005 | 0.964 | 0.005 | 0.964 | 0.005 | 0.990 | 0.000 | 0.927 | 0.005 | Download |
| ECFP4 fingerprints | 0.971 | 0.003 | 1.000 | 0.000 | 0.990 | 0.000 | 0.990 | 0.000 | 1.000 | 0.000 | 0.971 | 0.003 | Download |
| ECFP6 fingerprints | 0.938 | 0.004 | 1.000 | 0.000 | 0.969 | 0.003 | 0.968 | 0.004 | 0.990 | 0.000 | 0.938 | 0.004 | Download |
| Positive dataset | Negative dataset |
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E-mail: biomed@csu.edu.cn
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