Target name

Q9Y271: Cysteinyl leukotriene receptor 1


  Protein function

Receptor for cysteinyl leukotrienes mediating bronchoconstriction of individuals with and without asthma. Stimulation by LTD4 results in the contraction and proliferation of smooth muscle, edema, eosinophil migration and damage to the mucus layer in the lung. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. The rank order of affinities for the leukotrienes is LTD4 >> LTE4 = LTC4 >> LTB4.

  Database links

Uniprot primary ID Q9Y271
PDB ID
DrugBank ID DB01411 DB00471 DB00716 DB00549 DB00587
BioGrid ID 116014
GuidetoPHARMACOLOGY ID 269
PharmGKB ID PA38453
KEGG ID hsa:10800
DIP ID
STRING ID 9606.ENSP00000362401
IntAct ID Q9Y271
DMDM 20138087
BRENDA
Reactome R-HSA-391906 R-HSA-416476
SignaLink
BioCyc
Entrez Gene (Gene ID) 10800
BindingDB Q9Y271

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.958 0.004 0.982 0.004 0.970 0.000 0.970 0.000 0.990 0.000 0.939 0.003 Download
Estate fingerprints 0.868 0.004 0.872 0.007 0.870 0.000 0.870 0.000 0.950 0.000 0.741 0.007 Download
MACCS fingerprints 0.887 0.007 0.907 0.005 0.897 0.007 0.897 0.007 0.970 0.000 0.797 0.007 Download
Daylight fingerprints 0.894 0.007 0.980 0.000 0.937 0.005 0.934 0.005 0.980 0.000 0.874 0.007 Download
ECFP2 fingerprints 0.952 0.004 0.976 0.005 0.964 0.005 0.964 0.005 0.990 0.000 0.927 0.005 Download
ECFP4 fingerprints 0.971 0.003 1.000 0.000 0.990 0.000 0.990 0.000 1.000 0.000 0.971 0.003 Download
ECFP6 fingerprints 0.938 0.004 1.000 0.000 0.969 0.003 0.968 0.004 0.990 0.000 0.938 0.004 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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