Target name

Q9Y5N1: Histamine H3 receptor


  Protein function

The H3 subclass of histamine receptors could mediate the histamine signals in CNS and peripheral nervous system. Signals through the inhibition of adenylate cyclase and displays high constitutive activity (spontaneous activity in the absence of agonist). Agonist stimulation of isoform 3 neither modified adenylate cyclase activity nor induced intracellular calcium mobilization.

  Database links

Uniprot primary ID Q9Y5N1
PDB ID
DrugBank ID DB00370 DB06698 DB00667
BioGrid ID 116416
GuidetoPHARMACOLOGY ID 264
PharmGKB ID PA29458
KEGG ID hsa:11255
DIP ID DIP-61456N
STRING ID 9606.ENSP00000342560
IntAct ID
DMDM 17367264
BRENDA
Reactome R-HSA-418594 R-HSA-390650
SignaLink
BioCyc
Entrez Gene (Gene ID) 11255
BindingDB Q9Y5N1

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.861 0.003 0.819 0.000 0.840 0.000 0.840 0.000 0.920 0.000 0.677 0.005 Download
Estate fingerprints 0.830 0.000 0.754 0.004 0.792 0.004 0.800 0.000 0.870 0.000 0.590 0.000 Download
MACCS fingerprints 0.860 0.000 0.740 0.000 0.800 0.000 0.810 0.000 0.900 0.000 0.610 0.000 Download
Daylight fingerprints 0.680 0.000 0.780 0.000 0.730 0.000 0.720 0.000 0.810 0.000 0.468 0.004 Download
ECFP2 fingerprints 0.937 0.005 0.883 0.000 0.910 0.000 0.911 0.003 0.980 0.000 0.824 0.005 Download
ECFP4 fingerprints 0.940 0.000 0.960 0.000 0.950 0.000 0.950 0.000 0.990 0.000 0.900 0.000 Download
ECFP6 fingerprints 0.924 0.005 0.974 0.000 0.949 0.003 0.944 0.005 0.990 0.000 0.890 0.000 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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