Target name

O00329: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


  Protein function

Phosphoinositide-3-kinase (PI3K) that phosphorylates PftdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Mediates immune responses. Plays a role in B-cell development, proliferation, migration, and function. Required for B-cell receptor (BCR) signaling. Mediates B-cell proliferation response to anti-IgM, anti-CD40 and IL4 stimulation. Promotes cytokine production in response to TLR4 and TLR9. Required for antibody class switch mediated by TLR9. Involved in the antigen presentation function of B-cells. Involved in B-cell chemotaxis in response to CXCL13 and sphingosine 1-phosphate (S1P). Required for proliferation, signaling and cytokine production of naive, effector and memory T-cells. Required for T-cell receptor (TCR) signaling. Mediates TCR signaling events at the immune synapse. Activation by TCR leads to antigen-dependent memory T-cell migration and retention to antigenic tissues. Together with PIK3CG participates in T-cell development. Contributes to T-helper cell expansion and differentiation. Required for T-cell migration mediated by homing receptors SELL/CD62L, CCR7 and S1PR1 and antigen dependent recruitment of T-cells. Together with PIK3CG is involved in natural killer (NK) cell development and migration towards the sites of inflammation. Participates in NK cell receptor activation. Have a role in NK cell maturation and cytokine production. Together with PIK3CG is involved in neutrophil chemotaxis and extravasation. Together with PIK3CG participates in neutrophil respiratory burst. Have important roles in mast-cell development and mast cell mediated allergic response. Involved in stem cell factor (SCF)-mediated proliferation, adhesion and migration. Required for allergen-IgE-induced degranulation and cytokine release. The lipid kinase activity is required for its biological function. Isoform 2 may be involved in stabilizing total RAS levels, resulting in increased ERK phosphorylation and increased PI3K activity.

  Database links

Uniprot primary ID O00329
PDB ID
DrugBank ID DB00201
BioGrid ID 111311
GuidetoPHARMACOLOGY ID 2155
PharmGKB ID PA33310
KEGG ID hsa:5293
DIP ID
STRING ID 9606.ENSP00000366563
IntAct ID O00329
DMDM
BRENDA 2.7.1.137 2.7.1.153
Reactome R-HSA-1660499 R-HSA-983695 R-HSA-912631 R-HSA-1257604 R-HSA-114604 R-HSA-912526 R-HSA-2219530 R-HSA-392451 R-HSA-512988
SignaLink O00329
BioCyc MetaCyc:ENSG00000171608-MONOMER
Entrez Gene (Gene ID) 5293
BindingDB O00329

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.936 0.005 0.904 0.000 0.920 0.000 0.921 0.003 0.970 0.000 0.844 0.005 Download
Estate fingerprints 0.879 0.003 0.743 0.005 0.811 0.003 0.822 0.004 0.882 0.004 0.629 0.006 Download
MACCS fingerprints 0.929 0.003 0.791 0.000 0.860 0.000 0.870 0.000 0.930 0.000 0.725 0.005 Download
Daylight fingerprints 0.913 0.005 0.747 0.004 0.830 0.000 0.843 0.005 0.870 0.000 0.671 0.006 Download
ECFP2 fingerprints 0.962 0.004 0.910 0.005 0.936 0.005 0.939 0.003 0.980 0.000 0.874 0.005 Download
ECFP4 fingerprints 0.950 0.000 0.976 0.005 0.963 0.005 0.961 0.003 0.990 0.000 0.928 0.004 Download
ECFP6 fingerprints 0.924 0.005 0.990 0.003 0.957 0.005 0.950 0.000 0.989 0.003 0.910 0.000 Download

  Download datasets

Positive dataset Negative dataset


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School of Pharmaceutical Sciences, Central South University. All rights reserved.

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