Nonselective, high-affinity receptor for both orexin-A and orexin-B neuropeptides.
| Uniprot primary ID | O43614 |
| PDB ID | 4S0V |
| DrugBank ID | DB09034 |
| BioGrid ID | |
| GuidetoPHARMACOLOGY ID | 322 |
| PharmGKB ID | PA29223 |
| KEGG ID | hsa:3062 |
| DIP ID | |
| STRING ID | 9606.ENSP00000359899 |
| IntAct ID | |
| DMDM | |
| BRENDA | |
| Reactome | R-HSA-389397 R-HSA-416476 |
| SignaLink | |
| BioCyc | |
| Entrez Gene (Gene ID) | 3062 |
| BindingDB | O43614 |
| Fingerprint type | Sensitivity | SEN_std | Specificity | SPE_std | Accuracy | ACC_std | F1-score | F1-score_std | AUC | AUC_std | MCC | MCC_std | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.898 | 0.008 | 0.932 | 0.004 | 0.915 | 0.007 | 0.913 | 0.007 | 0.970 | 0.000 | 0.830 | 0.009 | Download |
| Estate fingerprints | 0.886 | 0.007 | 0.758 | 0.005 | 0.822 | 0.004 | 0.834 | 0.005 | 0.890 | 0.000 | 0.651 | 0.009 | Download |
| MACCS fingerprints | 0.857 | 0.005 | 0.775 | 0.005 | 0.816 | 0.005 | 0.823 | 0.005 | 0.910 | 0.000 | 0.636 | 0.008 | Download |
| Daylight fingerprints | 0.849 | 0.006 | 0.855 | 0.003 | 0.852 | 0.004 | 0.852 | 0.004 | 0.897 | 0.005 | 0.704 | 0.007 | Download |
| ECFP2 fingerprints | 0.933 | 0.007 | 0.963 | 0.004 | 0.948 | 0.004 | 0.946 | 0.005 | 0.990 | 0.000 | 0.893 | 0.005 | Download |
| ECFP4 fingerprints | 0.945 | 0.005 | 0.995 | 0.000 | 0.970 | 0.000 | 0.968 | 0.004 | 0.999 | 0.003 | 0.939 | 0.006 | Download |
| ECFP6 fingerprints | 0.896 | 0.005 | 0.996 | 0.000 | 0.946 | 0.005 | 0.943 | 0.005 | 1.000 | 0.000 | 0.896 | 0.005 | Download |
| Positive dataset | Negative dataset |
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E-mail: jiedong@csu.edu.cn
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