Target name

O43614: Orexin receptor type 2


  Protein function

Nonselective, high-affinity receptor for both orexin-A and orexin-B neuropeptides.

  Database links

Uniprot primary ID O43614
PDB ID 4S0V
DrugBank ID DB09034
BioGrid ID
GuidetoPHARMACOLOGY ID 322
PharmGKB ID PA29223
KEGG ID hsa:3062
DIP ID
STRING ID 9606.ENSP00000359899
IntAct ID
DMDM
BRENDA
Reactome R-HSA-389397 R-HSA-416476
SignaLink
BioCyc
Entrez Gene (Gene ID) 3062
BindingDB O43614

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.898 0.008 0.932 0.004 0.915 0.007 0.913 0.007 0.970 0.000 0.830 0.009 Download
Estate fingerprints 0.886 0.007 0.758 0.005 0.822 0.004 0.834 0.005 0.890 0.000 0.651 0.009 Download
MACCS fingerprints 0.857 0.005 0.775 0.005 0.816 0.005 0.823 0.005 0.910 0.000 0.636 0.008 Download
Daylight fingerprints 0.849 0.006 0.855 0.003 0.852 0.004 0.852 0.004 0.897 0.005 0.704 0.007 Download
ECFP2 fingerprints 0.933 0.007 0.963 0.004 0.948 0.004 0.946 0.005 0.990 0.000 0.893 0.005 Download
ECFP4 fingerprints 0.945 0.005 0.995 0.000 0.970 0.000 0.968 0.004 0.999 0.003 0.939 0.006 Download
ECFP6 fingerprints 0.896 0.005 0.996 0.000 0.946 0.005 0.943 0.005 1.000 0.000 0.896 0.005 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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