Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of these downstream effectors by MET leads to the activation of several signaling cascades including the RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC. The RAS-ERK activation is associated with the morphogenetic effects while PI3K/AKT coordinates prosurvival effects. During embryonic development, MET signaling plays a role in gastrulation, development and migration of muscles and neuronal precursors, angiogenesis and kidney formation. In adults, participates in wound healing as well as organ regeneration and tissue remodeling. Promotes also differentiation and proliferation of hematopoietic cells.
Uniprot primary ID | P08581 |
PDB ID | 3CTJ 2WGJ 4R1V 1SHY 4XMO 4R1Y 3CTH 3CCN 3BUX 2WKM 3VW8 3F82 1R1W 2WD1 3CD8 1FYR 4KNB 3QTI 4K3J 3ZXZ 2UZY 3ZC5 3LQ8 2G15 3I5N 3ZBX 3CE3 3A4P 4MXC 3L8V 2RFS 1R0P 4O3T 4O3U 3ZCL 3ZZE 3DKC 2RFN 3DKF 3DKG 4AOI 3Q6W 3R7O 3Q6U 3C1X 4IWD 4DEG 2UZX 4GG7 4GG5 4EEV |
DrugBank ID | DB08875 DB08865 |
BioGrid ID | 110391 |
GuidetoPHARMACOLOGY ID | 1815 |
PharmGKB ID | PA30763 |
KEGG ID | hsa:4233 |
DIP ID | DIP-6023N |
STRING ID | 9606.ENSP00000317272 |
IntAct ID | P08581 |
DMDM | 251757497 |
BRENDA | 2.7.10.1 |
Reactome | R-HSA-416550 |
SignaLink | P08581 |
BioCyc | |
Entrez Gene (Gene ID) | 4233 |
BindingDB | P08581 |
Fingerprint type | Sensitivity | SEN_std | Specificity | SPE_std | Accuracy | ACC_std | F1-score | F1-score_std | AUC | AUC_std | MCC | MCC_std | Download model |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
FP2 fingerprints | 0.832 | 0.004 | 0.888 | 0.003 | 0.860 | 0.000 | 0.858 | 0.004 | 0.940 | 0.000 | 0.722 | 0.004 | Download |
Estate fingerprints | 0.760 | 0.000 | 0.702 | 0.003 | 0.731 | 0.003 | 0.740 | 0.000 | 0.820 | 0.000 | 0.466 | 0.005 | Download |
MACCS fingerprints | 0.837 | 0.005 | 0.725 | 0.005 | 0.781 | 0.003 | 0.793 | 0.005 | 0.880 | 0.000 | 0.569 | 0.006 | Download |
Daylight fingerprints | 0.838 | 0.004 | 0.732 | 0.003 | 0.785 | 0.005 | 0.798 | 0.004 | 0.832 | 0.004 | 0.572 | 0.004 | Download |
ECFP2 fingerprints | 0.919 | 0.003 | 0.879 | 0.005 | 0.899 | 0.003 | 0.900 | 0.000 | 0.960 | 0.000 | 0.796 | 0.005 | Download |
ECFP4 fingerprints | 0.890 | 0.000 | 0.970 | 0.000 | 0.930 | 0.000 | 0.930 | 0.000 | 0.970 | 0.000 | 0.867 | 0.005 | Download |
ECFP6 fingerprints | 0.860 | 0.000 | 0.980 | 0.000 | 0.920 | 0.000 | 0.915 | 0.005 | 0.970 | 0.000 | 0.849 | 0.003 | Download |
Positive dataset | Negative dataset |
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E-mail: biomed@csu.edu.cn