Target name

P08581: Hepatocyte growth factor receptor


  Protein function

Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of these downstream effectors by MET leads to the activation of several signaling cascades including the RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC. The RAS-ERK activation is associated with the morphogenetic effects while PI3K/AKT coordinates prosurvival effects. During embryonic development, MET signaling plays a role in gastrulation, development and migration of muscles and neuronal precursors, angiogenesis and kidney formation. In adults, participates in wound healing as well as organ regeneration and tissue remodeling. Promotes also differentiation and proliferation of hematopoietic cells.

  Database links

Uniprot primary ID P08581
PDB ID 3CTJ 2WGJ 4R1V 1SHY 4XMO 4R1Y 3CTH 3CCN 3BUX 2WKM 3VW8 3F82 1R1W 2WD1 3CD8 1FYR 4KNB 3QTI 4K3J 3ZXZ 2UZY 3ZC5 3LQ8 2G15 3I5N 3ZBX 3CE3 3A4P 4MXC 3L8V 2RFS 1R0P 4O3T 4O3U 3ZCL 3ZZE 3DKC 2RFN 3DKF 3DKG 4AOI 3Q6W 3R7O 3Q6U 3C1X 4IWD 4DEG 2UZX 4GG7 4GG5 4EEV
DrugBank ID DB08875 DB08865
BioGrid ID 110391
GuidetoPHARMACOLOGY ID 1815
PharmGKB ID PA30763
KEGG ID hsa:4233
DIP ID DIP-6023N
STRING ID 9606.ENSP00000317272
IntAct ID P08581
DMDM 251757497
BRENDA 2.7.10.1
Reactome R-HSA-416550
SignaLink P08581
BioCyc
Entrez Gene (Gene ID) 4233
BindingDB P08581

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.832 0.004 0.888 0.003 0.860 0.000 0.858 0.004 0.940 0.000 0.722 0.004 Download
Estate fingerprints 0.760 0.000 0.702 0.003 0.731 0.003 0.740 0.000 0.820 0.000 0.466 0.005 Download
MACCS fingerprints 0.837 0.005 0.725 0.005 0.781 0.003 0.793 0.005 0.880 0.000 0.569 0.006 Download
Daylight fingerprints 0.838 0.004 0.732 0.003 0.785 0.005 0.798 0.004 0.832 0.004 0.572 0.004 Download
ECFP2 fingerprints 0.919 0.003 0.879 0.005 0.899 0.003 0.900 0.000 0.960 0.000 0.796 0.005 Download
ECFP4 fingerprints 0.890 0.000 0.970 0.000 0.930 0.000 0.930 0.000 0.970 0.000 0.867 0.005 Download
ECFP6 fingerprints 0.860 0.000 0.980 0.000 0.920 0.000 0.915 0.005 0.970 0.000 0.849 0.003 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

The recommended browsers: Safari, Firefox, Chrome, IE(Ver.>8).
 E-mail: biomed@csu.edu.cn