Responsible for the metabolism of many drugs and environmental chemicals that it oxidizes. It is involved in the metabolism of drugs such as antiarrhythmics, adrenoceptor antagonists, and tricyclic antidepressants.
| Uniprot primary ID | P10635 |
| PDB ID | 4XRZ 4XRY 3TDA 3TBG 2F9Q 3QM4 4WNU 4WNT 4WNW 4WNV |
| DrugBank ID | DB00951 DB00950 DB00956 DB01167 DB01166 DB01410 DB00674 |
| BioGrid ID | 107940 |
| GuidetoPHARMACOLOGY ID | |
| PharmGKB ID | PA128 |
| KEGG ID | hsa:1565 |
| DIP ID | |
| STRING ID | 9606.ENSP00000353820 |
| IntAct ID | |
| DMDM | 84028191 |
| BRENDA | 1.14.14.1 1.14.99.38 |
| Reactome | R-HSA-211999 R-HSA-211981 R-HSA-211935 R-HSA-211958 |
| SignaLink | |
| BioCyc | |
| Entrez Gene (Gene ID) | 1565 |
| BindingDB | P10635 |
| Fingerprint type | Sensitivity | SEN_std | Specificity | SPE_std | Accuracy | ACC_std | F1-score | F1-score_std | AUC | AUC_std | MCC | MCC_std | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.784 | 0.005 | 0.696 | 0.004 | 0.740 | 0.000 | 0.750 | 0.000 | 0.820 | 0.000 | 0.481 | 0.003 | Download |
| Estate fingerprints | 0.747 | 0.007 | 0.641 | 0.005 | 0.694 | 0.005 | 0.709 | 0.006 | 0.757 | 0.005 | 0.391 | 0.009 | Download |
| MACCS fingerprints | 0.791 | 0.003 | 0.649 | 0.005 | 0.720 | 0.000 | 0.740 | 0.000 | 0.770 | 0.000 | 0.443 | 0.005 | Download |
| Daylight fingerprints | 0.712 | 0.004 | 0.666 | 0.000 | 0.689 | 0.003 | 0.699 | 0.003 | 0.710 | 0.000 | 0.376 | 0.005 | Download |
| ECFP2 fingerprints | 0.811 | 0.003 | 0.829 | 0.005 | 0.820 | 0.000 | 0.819 | 0.003 | 0.900 | 0.000 | 0.637 | 0.005 | Download |
| ECFP4 fingerprints | 0.778 | 0.006 | 0.886 | 0.005 | 0.832 | 0.004 | 0.822 | 0.004 | 0.917 | 0.005 | 0.671 | 0.009 | Download |
| ECFP6 fingerprints | 0.743 | 0.005 | 0.897 | 0.000 | 0.820 | 0.000 | 0.810 | 0.000 | 0.905 | 0.005 | 0.654 | 0.005 | Download |
| Positive dataset | Negative dataset |
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E-mail: jiedong@csu.edu.cn
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