Target name

P10635: Cytochrome P450 2D6


  Protein function

Responsible for the metabolism of many drugs and environmental chemicals that it oxidizes. It is involved in the metabolism of drugs such as antiarrhythmics, adrenoceptor antagonists, and tricyclic antidepressants.

  Database links

Uniprot primary ID P10635
PDB ID 4XRZ 4XRY 3TDA 3TBG 2F9Q 3QM4 4WNU 4WNT 4WNW 4WNV
DrugBank ID DB00951 DB00950 DB00956 DB01167 DB01166 DB01410 DB00674
BioGrid ID 107940
GuidetoPHARMACOLOGY ID
PharmGKB ID PA128
KEGG ID hsa:1565
DIP ID
STRING ID 9606.ENSP00000353820
IntAct ID
DMDM 84028191
BRENDA 1.14.14.1 1.14.99.38
Reactome R-HSA-211999 R-HSA-211981 R-HSA-211935 R-HSA-211958
SignaLink
BioCyc
Entrez Gene (Gene ID) 1565
BindingDB P10635

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.784 0.005 0.696 0.004 0.740 0.000 0.750 0.000 0.820 0.000 0.481 0.003 Download
Estate fingerprints 0.747 0.007 0.641 0.005 0.694 0.005 0.709 0.006 0.757 0.005 0.391 0.009 Download
MACCS fingerprints 0.791 0.003 0.649 0.005 0.720 0.000 0.740 0.000 0.770 0.000 0.443 0.005 Download
Daylight fingerprints 0.712 0.004 0.666 0.000 0.689 0.003 0.699 0.003 0.710 0.000 0.376 0.005 Download
ECFP2 fingerprints 0.811 0.003 0.829 0.005 0.820 0.000 0.819 0.003 0.900 0.000 0.637 0.005 Download
ECFP4 fingerprints 0.778 0.006 0.886 0.005 0.832 0.004 0.822 0.004 0.917 0.005 0.671 0.009 Download
ECFP6 fingerprints 0.743 0.005 0.897 0.000 0.820 0.000 0.810 0.000 0.905 0.005 0.654 0.005 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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